Insights into the skin disease and systemic inflammation may come from evaluating skin and circulating proteins concurrently recently our group published a study of the skin transcriptome and serum protein measurements using a 92 protein multiplex luminex based panel in 85 patients with moderate to severe psoriasis compared with serum . S100a8 and s100a9 new insights into their roles in malignancy in mouse models of inflammation associated skin colon and liver carcinogenesis these studies provide compelling evidence for a causal role for s100a8 a9 in inflammatory diseases through interactions with tlr4. Psoriasis is a common heterogeneous inflammatory skin disease with a complex pathophysiology and limited treatment options here we performed proteomic analyses of human psoriatic epidermis and found s100a8 s100a9 also called calprotectin as the most upregulated proteins followed by the complement component c3. Two differentially expressed genes which exhibited a strong up regulation in advanced stages of skin cancer in mouse and human encode the s100 family members s100a8 and s100a9 fig 1 in addition significant alterations in the expression of other s100 members such as s100a3 s100a6 and s100a7 were found in skin tumors suggesting a functional role of s100 proteins during promotion . Request pdf on researchgate novel insights into the role of s100a8 a9 in skin biology s100a8 and s100a9 belong to the damage associated molecular pattern molecules they are upregulated in a
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