3 oxidative stress in neurodegeneration one of the most metabolically active organs of the body is the brain including the spinal cord comprising central nervous system cns which even at rest utilizes an estimated 20 of the total oxygen uptake. Oxidative stress and free radical generation catalyzed by redox metals have been shown to play pivotal role in regulating redox reactions in vivo contributing rns and ros main culprits in neurodegeneration while considering role of oxidative stress in neurodegeneration few important aspects need to be mentioned in brief are. Oxidative medicine and cellular longevity is a unique peer reviewed open access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging immune function vascular biology metabolism cellular survival and cellular longevity. It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases major source of oxidative stress due to reactive oxygen species ros is related to mitochondria as an endogenous source although there is ample evidence from tissues of patients with neurodegenerative disorders of morphological biochemical and molecular abnormalities in mitochondria it is . Despite the progress being made by researchers alzheimers disease along with other age related neurodegenerative disorders continues to exact a tremendous search all titles search all collections
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